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Article

Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients.

European journal of clinical pharmacology - 1 Jun 2013

Singkham Noppaket, Towanabut Somchai, Lertkachatarn Surang, Punyawudho Baralee

Abstract excerpt

BACKGROUND AND OBJECTIVES: A high inter-individual variability in the pharmacokinetics of lamotrigine has been observed. Lamotrigine is primarily metabolized by UGT1A4 and UGT2B7, both of which show genetic polymorphisms. Both genetic and non-genetic factors may influence the pharmacokinetics of lamotrigine. The aim of this study was to determine the pharmacokinetic parameters of lamotrigine and to investigate...

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Source

Identifiers

PMID: 23263737
DOI: 10.1007/s00228-012-1449-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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