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Article

Meta-analysis of the Influence of UGT Genetic Polymorphisms on Lamotrigine Concentration.

Basic & clinical pharmacology & toxicology - 1 Feb 2019

Kim Su Cheol, Kim Myeong Gyu

Abstract excerpt

Uridine 5'-diphospho-glucuronosyltransferases (UGTs) are involved in the metabolism of lamotrigine, but whether the UGT1A4 and UGT2B7 genetic polymorphisms affect lamotrigine concentration remains controversial. Thus, the objective of this meta-analysis was to analyse the influence of UGT1A4 and UGT2B7 genetic polymorphisms on lamotrigine concentration. Through searching, screening, selection, data extraction and...

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PMID: 30168665
DOI: 10.1111/bcpt.13120

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