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Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy.

Fundamental & clinical pharmacology - 1 Apr 2024

Šušak Sporiš Ivana, Božina Nada, Klarica Domjanović Iva, Sporiš Davor, Bašić Silvio, Bašić Ivana, Lovrić Mila, Ganoci Lana, Trkulja Vladimir

Abstract excerpt

BACKGROUND: Valproate inhibits clearance of lamotrigine and greatly increases its concentrations. We assessed whether this effect was moderated by a polymorphism (ABCG2 c.421C>A) of the breast cancer resistance protein. METHODS: In two consecutive independent studies in adults with epilepsy on lamotrigine monotherapy or cotreated with valproate: (i) Exposure to valproate was considered treatment, (ii)...

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Identifiers

PMID: 37793994
DOI: 10.1111/fcp.12958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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