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Article

Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy.

British journal of clinical pharmacology - 1 Sept 2018

Klarica Domjanović Iva, Lovrić Mila, Trkulja Vladimir, Petelin-Gadže Željka, Ganoci Lana, Čajić Ivana, Božina Nada

Abstract excerpt

AIMS: To investigate the impact of glucuronidation enzyme (UGT1A4*3 142T>G, UGT1A4*2 70C>A, UGT2B7 -161C>T) and transporter (MDR1/ABCB1 1236C>T, ABCG2 421C>A) polymorphisms on steady-state disposition of lamotrigine and on the lamotrigine-valproate interaction. METHODS: Adults with epilepsy on lamotrigine monotherapy (n = 131) or lamotrigine + valproate treatment (n = 74) were genotyped and steady-state...

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Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

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Source

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Identifiers

PMID: 29791014
DOI: 10.1111/bcp.13646
PMCID: PMC6089815

Genes

ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy.PMID 29791014Read ↗

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Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C>T (rs7668258) or UGT1A4*3 c.142T>G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsySemantic proximity Read ↗

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