Effect of transporter gene polymorphisms and valproate co-medication on the steady-state disposition of lamotrigine and their effect on efficacy in adults with epilepsy.

Abstract excerpt

Background and Objectives The steady-state disposition lamotrigine (LTG) varies widely among patients with epilepsy, especially in the presence of concomitant antiseizure drugs. In this study, we investigate the potential role of transporter gene polymorphisms in ABCC1, ABCC2, ABCG2, SLCO1A2 and SLCO1B1 on the steady-state disposition of LTG and on the lamotrigine-valproate (LTG-VPA) interaction, and their effect...

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• Anticonvulsants
• ATP Binding Cassette Transporter, Subfamily G, Member 2
• Drug Interactions
• Lamotrigine
• Liver-Specific Organic Anion Transporter 1