Article
Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.
European journal of clinical pharmacology - 1 Aug 2023
Božina Nada, Sporiš Ivana Šušak, Domjanović Iva Klarica, Ganoci Lana, Šimičević Livija, Lovrić Mila, Romić Zrinka Čolak, Gadže Željka Petelin, Trkulja Vladimir
Abstract excerpt
PURPOSE: To estimate whether epilepsy patients with variant UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) alleles differ from their wild-type (wt) peers in exposure to lamotrigine. METHODS: Consecutive adults on lamotrigine monotherapy or lamotrigine + valproate co-treatment undergoing routine therapeutic drug monitoring, otherwise generally healthy and free of interacting drugs, were genotyped...
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