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Article

Influence of UGT2B7, UGT1A4 and ABCG2 Polymorphisms on the Pharmacokinetics and Therapeutic Efficacy of Lamotrigine in Patients with Epilepsy.

European journal of drug metabolism and pharmacokinetics - 1 Jul 2024

Yang Jing, Wang Jinxingyi, Ning Lijie, Wu Changsong, Liu Yang, Xia Jie, Guan Yanping, Liu Qian, Zheng Jianghuan

Abstract excerpt

BACKGROUND AND OBJECTIVES: A substantial inter-individual variability has been observed in the pharmacokinetics of lamotrigine. The aim of the study was to investigate the impact of genetic polymorphism of the metabolizing enzymes (UGT2B7, UGT1A4) and transporter (ABCG2) on the pharmacokinetics and therapeutic efficacy of lamotrigine in patients with epilepsy. METHODS: The genetic analysis of single-nucleotide...

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Identifiers

PMID: 38709450
DOI: 10.1007/s13318-024-00894-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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