Article

Fission yeast polycystin Pkd2p promotes the cell expansion and antagonizes the Hippo pathway SIN

2021-05-22

Abstract excerpt

Polycystins are conserved mechanosensitive channels whose mutations lead to the common human renal disorder ADPKD. Previously we discovered that the plasma membrane-localized fission yeast homologue Pkd2p is an essential protein required for cytokinesis, but the mechanism remains unclear. Here, we isolated a novel temperature-sensitive mutant pkd2-B42. Among its strong growth defects, the most unique was that man...

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Literature Corpus work: 28644425-e439-50d5-b527-be9232c1282a
DOI: 10.1101/2021.05.21.444707

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