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Article

Steric hindrance in the upper 50 kDa domain of the motor Myo2p leads to cytokinesis defects in fission yeast.

Journal of cell science - 4 Jan 2018

Palani Saravanan, Srinivasan Ramanujam, Zambon Paola, Kamnev Anton, Gayathri Pananghat, Balasubramanian Mohan K

Abstract excerpt

Cytokinesis in many eukaryotes requires a contractile actomyosin ring that is placed at the division site. In fission yeast, which is an attractive organism for the study of cytokinesis, actomyosin ring assembly and contraction requires the myosin II heavy chain Myo2p. Although myo2-E1, a temperature-sensitive mutant defective in the upper 50 kDa domain of Myo2p, has been studied extensively, the molecular basis...

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Identifiers

PMID: 29162650
DOI: 10.1242/jcs.205625
PMCID: PMC5818058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Steric hindrance in the upper 50 kDa domain of the motor Myo2p leads to cytokinesis defects in fission yeast.PMID 29162650Read ↗

Type II myosin involved in cytokinesis in the fission yeast,Schizosaccharomyces pombeSemantic proximity Read ↗

Identification of a second myosin-II in Schizosaccharomyces pombe: Myp2p is conditionally required for cytokinesis.Semantic proximity Read ↗

Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring.Semantic proximity Read ↗

Type II myosin heavy chain encoded by the myo2 gene composes the contractile ring during cytokinesis in Schizosaccharomyces pombe.Semantic proximity Read ↗

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Genetic suppression of defective profilin by attenuated Myosin II reveals a potential role for Myosin II in actin dynamics in vivo in fission yeast.Semantic proximity Read ↗

Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesisSemantic proximity Read ↗

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Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II.Semantic proximity Read ↗

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