Article

Role of Dynamin 2 in mitochondrial fission and cell cycle regulation:<i>Dysregulation of a miR-124-3p-STAT3-DNM2-Drp1-RGCC pathway connects fission and cell proliferation in pulmonary arterial hypertension</i>

2024-12-08

Abstract excerpt

<h4>Introduction</h4> Dynamin-related protein 1 (Drp1) activation increases mitochondrial fission and cell cycle progression in hyperproliferative cells, termed mitotic fission . However, the diameter of a fission apparatus comprised solely of Drp1 and its binding partners appears insufficient to complete fission. Moreover, the mechanism linking fission to cell cycle progression is unknown, suggesting an additiona...

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Literature Corpus work: e7a9ca46-e32d-5781-bcb1-489880b56962
DOI: 10.1101/2024.12.05.24318153

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