Article

Isoform-specific regulation of rhythmic gene expression by alternative polyadenylation

2020-12-13

Abstract excerpt

<h4>Summary</h4> Alternative polyadenylation (APA) generates transcript isoforms with different 3’ ends. Differences in polyadenylation sites usage, which have been associated with diseases like cancer, regulate mRNA stability, subcellular localization, and translation. By characterizing APA across the 24-hour day in mouse liver, here we show that rhythmic gene expression occurs largely in an APA isoform-specific...

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Literature Corpus work: 28542a51-3b14-5af3-86c2-675dfe1ac890
DOI: 10.1101/2020.12.12.422514

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