Article

Hypoxia-mediated fine-tuning of the TLR7/9-triggered human PDC-derived IFN-α response is mediated by combined cellular and soluble IFN-regulators

2024-09-19

Abstract excerpt

Hypoxia occurs in settings where stringent control of inflammation is mandatory to avoid tissue damage. Here, we analyzed how hypoxia-induced mediators alter recognition of pathogen-derived molecular patterns (PAMPs). The most relevant finding was that hypoxia selectively targets IFN-α induced upon stimulation with nucleic acid-sensing Toll-like receptors (TLR7/8 and -9) in PBMC. Notably, IFN-α secretion was reduc...

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Literature Corpus work: 2837cbf6-d89e-58c8-a5e8-d9e63ea497e1
DOI: 10.1101/2024.09.15.613102

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Hypoxia-mediated fine-tuning of the TLR7/9-triggered human PDC-derived IFN-α response is mediated by combined cellular and soluble IFN-regulatorsDOI 10.1101/2024.09.15.613102Read

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