Article

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Pre-mRNA splicing is a crucial process in eukaryotic gene expression, and splicing dysregulation has been linked to various diseases. However, very few small molecules have been discovered that can modulate spliced mRNA formation or inhibit the splicing machinery itself. This study presents a novel high-throughput screening (HTS) platform for identifying compounds that modulate splicing. Our pla...

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Literature Corpus work: 9cf9d793-446a-589e-919b-e6e32d91aad0
DOI: 10.1101/2025.10.20.683303

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