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Article

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.

Science (New York, N.Y.) - 23 May 2008

Bouatia-Naji Nabila, Rocheleau Ghislain, Van Lommel Leentje, Lemaire Katleen, Schuit Frans, Cavalcanti-Proença Christine, Marchand Marion, Hartikainen Anna-Liisa, Sovio Ulla, De Graeve Franck, Rung Johan, Vaxillaire Martine, Tichet Jean, Marre Michel, Balkau Beverley, Weill Jacques, Elliott Paul, Jarvelin Marjo-Riitta, Meyre David, Polychronakos Constantin, Dina Christian, Sladek Robert, Froguel Philippe

Abstract excerpt

Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels at the high end of the normal range have an increased risk of mortality. To identify genetic determinants that contribute to interindividual variation in FPG, we tested 392,935 single-nucleotide polymorph...

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Identifiers

PMID: 18451265
DOI: 10.1126/science.1156849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18451265-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.PMID 18451265Read ↗

A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population.Semantic proximity Read ↗

Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals.Semantic proximity Read ↗

Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.Semantic proximity Read ↗

Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.Semantic proximity Read ↗

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.Semantic proximity Read ↗

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.Semantic proximity Read ↗

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.Semantic proximity Read ↗

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.Semantic proximity Read ↗

Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.Semantic proximity Read ↗

HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2).Semantic proximity Read ↗

Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.Semantic proximity Read ↗

Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.Semantic proximity Read ↗

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