Article
Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.
Diabetes - 1 Oct 2010
Bouatia-Naji Nabila, Bonnefond Amélie, Baerenwald Devin A, Marchand Marion, Bugliani Marco, Marchetti Piero, Pattou François, Printz Richard L, Flemming Brian P, Umunakwe Obi C, Conley Nicholas L, Vaxillaire Martine, Lantieri Olivier, Balkau Beverley, Marre Michel, Lévy-Marchal Claire, Elliott Paul, Jarvelin Marjo-Riitta, Meyre David, Dina Christian, Oeser James K, Froguel Philippe, O'Brien Richard M
Abstract excerpt
OBJECTIVE: Genome-wide association studies have identified a single nucleotide polymorphism (SNP), rs560887, located in a G6PC2 intron that is highly correlated with variations in fasting plasma glucose (FPG). G6PC2 encodes an islet-specific glucose-6-phosphatase catalytic subunit. This study examines the contribution of two G6PC2 promoter SNPs, rs13431652 and rs573225, to the association signal. RESEARCH DESIGN...
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