Article

Causal Genes and Immune-Epigenetic Mechanisms Underlying Polycystic Ovary Syndrome: A Multi-Omics Mendelian Randomization Study

2025-09-30

Abstract excerpt

<title>Abstract</title> <p> Background Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder, yet its genetic basis remains incompletely understood. This study aimed to identify causal genes and elucidate upstream epigenetic and immune cell–specific regulatory mechanisms using a multi-omics Mendelian randomization (MR) framework. Methods We performed two-sample MR analyses using expression qu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28130efb-f112-5aff-b35b-ffe74cab1316
DOI: 10.21203/rs.3.rs-7532908/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Causal Genes and Immune-Epigenetic Mechanisms Underlying Polycystic Ovary Syndrome: A Multi-Omics Mendelian Randomization StudyDOI 10.21203/rs.3.rs-7532908/v1Read

sc-eQTL unveil Immunogenetic Architecture of Polycystic Ovary SyndromeSemantic proximity Read

sc-eQTL unveil immunogenetic architecture of polycystic ovary syndrome.Semantic proximity Read

Mendelian randomization analysis identified potential genes pleiotropically associated with polycystic ovary syndromeSemantic proximity Read

Integrative multi-omics analysis of druggable genes for therapeutic target identification in polycystic ovary syndrome.Semantic proximity Read

Mapping the causal landscape of polycystic ovary syndrome: A systematic Mendelian randomization evidence synthesis and the MR-PCOS atlas platform.Semantic proximity Read

An integrative multi-omics analysis of 16 autoimmune diseases and cancer outcomes highlights immune-cell regulatory mechanisms and shared genetic architectureSemantic proximity Read

From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis.Semantic proximity Read

Causal association of immune cells and polycystic ovarian syndrome: a Mendelian randomization studySemantic proximity Read

Unraveling the role of lipid metabolism in polycystic ovary syndrome through multi-omics Mendelian randomization.Semantic proximity Read

Integrative Multi-omics Analysis for Prioritization of Candidate Genes in Polycystic Ovary Syndrome.Semantic proximity Read

The Association Between Genetically Predicted Systemic Inflammatory Regulators and Polycystic Ovary Syndrome: A Mendelian Randomization Study.Semantic proximity Read

Mendelian Randomization Analysis Identified Potential Genes Pleiotropically Associated with Polycystic Ovary Syndrome.Semantic proximity Read