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Unraveling the role of lipid metabolism in polycystic ovary syndrome through multi-omics Mendelian randomization.

Journal of ovarian research - 9 Feb 2026

He Ronghuan, Tu Xiaoyu, Liu Bei, Jiang Zeyi, Chen Jin, Li Jingyi

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) is increasingly recognized as a metabolic disorder, with dysregulated lipid metabolism emerging as a key factor in its pathogenesis. However, the precise mechanisms underlying this relationship remain unclear. We employed a summary data-based Mendelian randomization (SMR) approach to investigate the potential causal relationships between lipid metabolism-related genes...

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DNA Methylation
Genome-Wide Association Study
Lipid Metabolism
Mendelian Randomization Analysis
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Ovary Syndrome

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Open in PubMed Open full text

Identifiers

PMID: 41664201
DOI: 10.1186/s13048-026-02014-z
PMCID: PMC12983665

Genes

GLIPR1
ACOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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