Article

Analysis of nucleus and cytoplasm-specific RNA fractions demonstrates that a significant proportion of the genetic regulation of gene expression across the human brain occurs post-transcriptionally

2022-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Gaining insight into the genetic regulation of gene expression in human brain is key to the interpretation of genome-wide association studies for major neurological and neuropsychiatric diseases. Expression quantitative trait loci (eQTL) analyses have largely been used to achieve this, providing valuable insights into the genetic regulation of steady-state RNA in human brain, but not distinguish...

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Literature Corpus work: 690b406f-59b7-58d4-8848-ae5b9bac1d89
DOI: 10.1101/2022.06.28.497921

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