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Article

Structural Lessons From the Mutant Proinsulin Syndrome.

Frontiers in endocrinology - 1 Jan 2021

Dhayalan Balamurugan, Chatterjee Deepak, Chen Yen-Shan, Weiss Michael A

Abstract excerpt

Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene (INS). Such mutations cause pancreatic β-cell dysfunction due to toxic misfolding of a mutant proinsulin and impairment in trans of wild-type insulin secretion. Anticipated by the "Akita" mouse (a classical model of monogenic diabetes mellitus; DM), this syndrome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34659132
DOI: 10.3389/fendo.2021.754693
PMCID: PMC8514764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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