Article

FK506-binding protein 2 participates in proinsulin folding

2022-12-12

Abstract excerpt

Apart from chaperoning, disulphide bond formation and downstream processing, the molecular sequence of proinsulin folding is not completely understood. Proinsulin requires proline isomerization for correct folding. Since FK506-binding protein 2 (FKBP2) is an ER-resident proline isomerase, we hypothesized that FKBP2 contributes to proinsulin folding. We found that FKBP2 co-immunoprecipitated with proinsulin and its...

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Literature Corpus work: 672e7385-aea4-549e-94d1-cb0a0c7815b6
DOI: 10.1101/2022.12.12.520056

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