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Article

Biosynthesis, structure, and folding of the insulin precursor protein.

Diabetes, obesity & metabolism - 1 Sept 2018

Liu Ming, Weiss Michael A, Arunagiri Anoop, Yong Jing, Rege Nischay, Sun Jinhong, Haataja Leena, Kaufman Randal J, Arvan Peter

Abstract excerpt

Insulin synthesis in pancreatic β-cells is initiated as preproinsulin. Prevailing glucose concentrations, which oscillate pre- and postprandially, exert major dynamic variation in preproinsulin biosynthesis. Accompanying upregulated translation of the insulin precursor includes elements of the endoplasmic reticulum (ER) translocation apparatus linked to successful orientation of the signal peptide, translocation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30230185
DOI: 10.1111/dom.13378
PMCID: PMC6463291

Genes

INS

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