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Article

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

Annals of the New York Academy of Sciences - 1 Apr 2018

Arunagiri Anoop, Haataja Leena, Cunningham Corey N, Shrestha Neha, Tsai Billy, Qi Ling, Liu Ming, Arvan Peter

Abstract excerpt

The endoplasmic reticulum (ER) is broadly distributed throughout the cytoplasm of pancreatic beta cells, and this is where all proinsulin is initially made. Healthy beta cells can synthesize 6000 proinsulin molecules per second. Ordinarily, nascent proinsulin entering the ER rapidly folds via the formation of three evolutionarily conserved disulfide bonds (B7-A7, B19-A20, and A6-A11). A modest amount of...

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PMID: 29377149
DOI: 10.1111/nyas.13531
PMCID: PMC5934315

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INS

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