Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.

EMBO molecular medicine - 1 Jun 2014

Lee Samuel, Min Kim Soo, Dotimas James, Li Letitia, Feener Edward P, Baldus Stephan, Myers Ronald B, Chutkow William A, Patwari Parth, Yoshioka Jun, Lee Richard T

Abstract excerpt

The endoplasmic reticulum (ER) is responsible for protein folding, modification, and trafficking. Accumulation of unfolded or misfolded proteins represents the condition of ER stress and triggers the unfolded protein response (UPR), a key mechanism linking supply of excess nutrients to insulin resistance and type 2 diabetes in obesity. The ER harbors proteins that participate in protein folding including protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Knockout Techniques

Share to Protein Disulfide-Isomerases

Share to Thioredoxins

Share to Ubiquitination

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 24843047
DOI: 10.15252/emmm.201302561
PMCID: PMC4203352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.PMID 24843047Read ↗

Minireview: Thioredoxin-Interacting Protein: Regulation and Function in the Pancreatic β-CellSemantic proximity Read ↗

Protein Disulfide Isomerases Function as the Missing Link Between Diabetes and CancerSemantic proximity Read ↗

Mutations in the Txnip PPXY motifs protect against myocardial infarction despite enhanced protein stability.Semantic proximity Read ↗

The UPRosome – decoding novel biological outputs of IRE1α functionSemantic proximity Read ↗

The Unfolded Protein Response in Health and DiseaseSemantic proximity Read ↗

A reference map of the human proinsulin biosynthetic interaction networkSemantic proximity Read ↗

TXNIP Links Anticipatory Unfolded Protein Response to Estrogen Reprogramming Glucose Metabolism in Breast Cancer Cells.Semantic proximity Read ↗

Intracellular Signaling by the Unfolded Protein ResponseSemantic proximity Read ↗

ER stress and diseases.Semantic proximity Read ↗

Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes.Semantic proximity Read ↗

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and DiseaseSemantic proximity Read ↗

The Role of Endoplasmic Reticulum Stress in Human PathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.