Article

Subtyping of obesity and type 2 diabetes using genetic discordance: a phenome-wide comparative analysis

2022-05-10

Abstract excerpt

<title>Abstract</title> <p>Obesity and type 2 diabetes are causally related, yet the underlying mechanisms are poorly defined. We aimed to subclassify obesity into etiological subtypes using a genetic-driven agnostic approach. Genetic instruments for body mass index and type 2 diabetes were classified into profiles that convey highly concordant (48 SNPs) and discordant (19 SNPs) diabetogenic effects. We annotated...

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Literature Corpus work: 27f07bbe-2b80-58e1-91f3-2013d7530265
DOI: 10.21203/rs.3.rs-1171707/v1

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