Article
A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes.
Nature metabolism - 1 Feb 2023
Coral Daniel E, Fernandez-Tajes Juan, Tsereteli Neli, Pomares-Millan Hugo, Fitipaldi Hugo, Mutie Pascal M, Atabaki-Pasdar Naeimeh, Kalamajski Sebastian, Poveda Alaitz, Miller-Fleming Tyne W, Zhong Xue, Giordano Giuseppe N, Pearson Ewan R, Cox Nancy J, Franks Paul W
Abstract excerpt
Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in the consequences of both conditions and the mechanisms of action are poorly defined. Here we show a genetic-driven approach defining two obesity profiles that convey highly concordant and discordant diabetogenic effects. We annotate and then compare association signals for these profiles across clinical and molecular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.