Article

LRRK2 exonic variants associated with Parkinson’s disease augment phosphorylation levels for LRRK2-Ser1292 and Rab10-Thr73

2018-10-22

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is associated to Parkinson’s disease (PD). The most common form of LRRK2 PD is caused by the G2019S variant. Besides G2019S, eight other LRRK2 variants causing familial PD also have amino acid substitutions located in a LRRK2 enzymatic domainsuggesting that enzymatic activity is at the core of mechanisms underlying disease risk. Common LRRK2 polymorphic risk variations such as...

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Literature Corpus work: d9227085-21b4-572d-abab-7af150e47587
DOI: 10.1101/447946

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