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A predicted deleterious allele of the essential meiosis gene <i>MND1</i> , present in ~3% of East Asians, does not disrupt reproduction in mice

2019-06-18

Abstract excerpt

Infertility is a major health problem affecting ~15% of couples worldwide. Except for cases involving readily-detectable chromosome aberrations, confident identification of a causative genetic defect is problematic. Despite the advent of genome sequencing for diagnostic purposes, the preponderance of segregating genetic variants complicates identification of culprit genetic alleles or mutations. Many algorithms ha...

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Literature Corpus work
27ce8b82-7edd-51e7-b7c2-d4a6deb5a0d3
DOI
10.1101/673145
Open publication

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A predicted deleterious allele of the essential meiosis gene <i>MND1</i> , present in ~3% of East Asians, does not disrupt reproduction in miceDOI 10.1101/673145
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