Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.

Human reproduction (Oxford, England) - 3 Apr 2023

Westerich Kim Joana, Reinecke Solveig, Emich Jana, Wyrwoll Margot Julia, Stallmeyer Birgit, Meyer Matthias, Oud Manon S, Fietz Daniela, Pilatz Adrian, Kliesch Sabine, Reichman-Fried Michal, Tarbashevich Katsiaryna, Limon Tamara, Stehling Martin, Friedrich Corinna, Tüttelmann Frank, Raz Erez

Abstract excerpt

STUDY QUESTION: Is the vertebrate protein Dead end (DND1) a causative factor for human infertility and can novel in vivo assays in zebrafish help in evaluating this? SUMMARY ANSWER: Combining patient genetic data with functional in vivo assays in zebrafish reveals a possible role for DND1 in human male fertility. WHAT IS KNOWN ALREADY: About 7% of the male population is affected by infertility but linking...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fertility
Share to Infertility, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to Phenotype

Share to Testis

Share to Zebrafish

Source

Identifiers

PMID: 36807972
DOI: 10.1093/humrep/dead031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos.PMID 36807972Read ↗

A homozygous missense variant in DND1 causes non-obstructive azoospermia in humansSemantic proximity Read ↗

A de novo paradigm for male infertilitySemantic proximity Read ↗

A <i>de novo</i> paradigm for male infertilitySemantic proximity Read ↗

Toward clinical exomes in diagnostics and management of male infertility.Semantic proximity Read ↗

Point-of-care whole-exome sequencing of idiopathic male infertility.Semantic proximity Read ↗

Biallelic mutations in <i>M1AP</i> are a frequent cause of meiotic arrest leading to male infertilitySemantic proximity Read ↗

A systematic review and evidence assessment of monogenic gene-disease relationships in human female infertility and differences in sex development.Semantic proximity Read ↗

Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.Semantic proximity Read ↗

A predicted deleterious allele of the essential meiosis gene <i>MND1</i> , present in ~3% of East Asians, does not disrupt reproduction in miceSemantic proximity Read ↗

A de novo paradigm for male infertility.Semantic proximity Read ↗

Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel.Semantic proximity Read ↗

Functional assessment of DMRT1 variants and their pathogenicity for isolated male infertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.