Comprehensive pan-cancer multi-omics analysis of PSMB7 reveals its prognostic significance and oncogenic role with experimental validation in lung and gastric cancers

Abstract excerpt

<title>Abstract</title> <p>Objective PSMB7 is a key component of the ATP-dependent proteolytic complex and plays an essential role in cellular protein degradation. While emerging evidence suggests its involvement in cancer, its roles in tumor progression, prognosis, and diagnosis remain largely uncharacterized. This study aimed to investigate the expression profile of PSMB7 and its association with clinical outco...

Topics

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• Autophagy in Disease and Therapy
• Cancer Genomics and Diagnostics
• Epigenetics and DNA Methylation
• Ferroptosis and cancer prognosis
• Histone Deacetylase Inhibitors Research
• Lung Cancer Treatments and Mutations
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

594c0365-7d92-5547-b66b-e3e384d25308

DOI

10.21203/rs.3.rs-7125983/v1