Article

Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues

2025-02-01

Abstract excerpt

Mitochondrial stress activates the integrated stress response (ISR) and triggers cell–cell communication through the secretion of the metabokine growth differentiation factor 15 (GDF15). However, the gene network underlying the ISR remains poorly defined, particularly across metabolically diverse cellular states and tissues. Using RNAseq data from fibroblasts subjected to eleven metabolic perturbations, including...

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Literature Corpus work: 27b62440-d949-5c27-b17e-9164864f9283
DOI: 10.1101/2025.01.31.635929

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