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Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity

16 Feb 2022

Abstract excerpt

Growth differentiation factor 15 (GDF-15) is a transforming growth factor (TGF)-β superfamily cytokine that plays a central role in metabolism regulation. Produced in response to mitochondrial stress, tissue damage or hypoxia, this cytokine has emerged as one of the strongest predictors of disease severity during inflammatory conditions, cancers and infections. Reports suggest that GDF-15 plays a tissue...

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PMID: 35251002
DOI: 10.3389/fimmu.2022.820350

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