Article

Growth Differentiation Factor 15 Connects Stress and Ageing in a UK Biobank Cohort

2025-07-05

Abstract excerpt

<h4>Background</h4> The brain–body energy-conservation model proposes that signals from metabolically active senescent cells, including growth differentiation factor 15 (GDF15), prompt the brain to downregulate systemic energy expenditure, leading to functional decline. However, large-scale human studies testing this hypothesis are lacking. We examined whether circulating GDF15 is associated with physiological an...

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Literature Corpus work: d70b01f4-fc17-5c94-b0f2-ee6cad92e563
DOI: 10.1101/2025.07.04.25330886

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