Article

Orthologs of Human Circulating miRNAs Associated with Hepatocellular Carcinoma Are Elevated in Mouse Plasma Months before Tumour Detection

2022-03-30

Abstract excerpt

Research examining the potential for circulating miRNA as serve as markers for preneoplastic lesions or early-stage hepatocellular carcinoma (HCC) is hindered by the difficulties of obtaining samples from asymptomatic individuals. As a surrogate for human samples, we identified hub miRNAs in gene co-expression networks using HCC-bearing C3H mice. We confirmed 38 hub miRNAs as associated with HCC in F2 hybrid mice...

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Literature Corpus work: 2762b0a7-f308-534d-842c-aaa1c92cee39
DOI: 10.21203/rs.3.rs-1486225/v1

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