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Article

Induction of hepatocellular carcinoma by in vivo gene targeting.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012

Wang Pei-Rong, Xu Mei, Toffanin Sara, Li Yi, Llovet Josep M, Russell David W

Abstract excerpt

The distinct phenotypic and prognostic subclasses of human hepatocellular carcinoma (HCC) are difficult to reproduce in animal experiments. Here we have used in vivo gene targeting to insert an enhancer-promoter element at an imprinted chromosome 12 locus in mice, thereby converting ∼1 in 20,000 normal hepatocytes into a focus of HCC with a single genetic modification. A 300-kb chromosomal domain containing...

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Identifiers

PMID: 22733778
DOI: 10.1073/pnas.1117032109
PMCID: PMC3396480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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