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Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

1 Oct 2007

Abstract excerpt

Internal human xenografts provide valuable animal models to study the microenvironments and metastatic processes occurring in human cancers. However, the use of such models is hampered by the logistical difficulties of reproducibly and simply assessing tumor burden. We developed a high-sensitivity assay for quantifying human DNA in small volumes of mouse plasma, enabling in-life monitoring of systemic tumor...

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PMID: 17909045
DOI: 10.1158/0008-5472.can-07-0605

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