Article
Human-correlated genetic models identify precision therapy for liver cancer.
Nature - 1 Mar 2025
Müller Miryam, May Stephanie, Hall Holly, Kendall Timothy J, McGarry Lynn, Blukacz Lauriane, Nuciforo Sandro, Georgakopoulou Anastasia, Jamieson Thomas, Phinichkusolchit Narisa, Dhayade Sandeep, Suzuki Toshiyasu, Huguet-Pradell Júlia, Powley Ian R, Officer-Jones Leah, Pennie Rachel L, Esteban-Fabró Roger, Gris-Oliver Albert, Pinyol Roser, Skalka George L, Leslie Jack, Hoare Matthew, Sprangers Joep, Malviya Gaurav, Mackintosh Agata, Johnson Emma, McCain Misti, Halpin John, Kiourtis Christos, Nixon Colin, Clark Graeme, Clark William, Shaw Robin, Hedley Ann, Drake Thomas M, Tan Ee Hong, Neilson Matt, Murphy Daniel J, Lewis David Y, Reeves Helen L, Le Quesne John, Mann Derek A, Carlin Leo M, Blyth Karen, Llovet Josep M, Heim Markus H, Sansom Owen J, Miller Crispin J, Bird Thomas G
Abstract excerpt
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide1,2. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing conditions. Tumour development is driven by the expansion of clones that accumulate progressive driver mutations3, with hepatocytes the most likely cell of origin2. However,...
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