Article
Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages.
Annals of the rheumatic diseases - 1 Feb 2022
Geng Linyu, Zhao Jian, Deng Yun, Molano Ivan, Xu Xue, Xu Lingxiao, Ruiz Phillip, Li Quanzhen, Feng Xuebing, Zhang Miaojia, Tan Wenfeng, Kamen Diane L, Bae Sang-Cheol, Gilkeson Gary S, Sun Lingyun, Tsao Betty P
Abstract excerpt
OBJECTIVES: We previously identified a hypomorphic variant, p.Arg90His (p.R90H) of neutrophil cytosolic factor 1 (NCF1, a regulatory subunit of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 complex), as an putative causal variant for systemic lupus erythematosus (SLE), and established a knock-in (KI) H90 variant in the C57BL/6 background to study how this variant promotes lupus...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.