Article

Role of glycine- <i>N</i> -methyl transferase in human and murine nonalcoholic steatohepatitis

2021-12-03

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of chronic liver disease worldwide, mirroring the obesity epidemic. NAFLD is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). This significantly increases the risk of cirrhosis and decompensated liver failure. Past studies in rodent models have show...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27410f3c-5608-5dfc-ba60-e12d865b44f1
DOI: 10.1101/2021.12.03.470998

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role of glycine- <i>N</i> -methyl transferase in human and murine nonalcoholic steatohepatitisDOI 10.1101/2021.12.03.470998Read

Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated CarcinogenesisSemantic proximity Read

GNMT and Its Regulatory MicroRNAs as Biomarkers and Therapeutic Targets for Metabolic Dysfunction-Associated Fatty Liver Disease and Hepatocellular CarcinomaSemantic proximity Read

Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLDSemantic proximity Read

Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLDSemantic proximity Read

Rewired NAD <sup>+</sup> metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progressionSemantic proximity Read

A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models.Semantic proximity Read

Nicotinamide N-methyltransferase couples inflammation and epigenetic remodelling to hepatic fibrosisSemantic proximity Read

Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.Semantic proximity Read

Glycine promotes longevity in <i>Caenorhabditis elegans</i> in a methionine cycle-dependent fashionSemantic proximity Read

Argininosuccinate Synthase 1 links hepatic urea cycle to whole body lipid metabolismSemantic proximity Read

Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes.Semantic proximity Read

A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.Semantic proximity Read