Article
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.
Transgenic research - 1 Jun 2006
Luka Zigmund, Capdevila Antonieta, Mato José M, Wagner C
Abstract excerpt
Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have been reported. This enzyme transfers a methyl group from S-adenosylmethionine (SAM) to glycine to form S-adenosylhomocysteine (SAH) and N-methylglycine (sarcosine) and is believed to be involved in the regulation of methylation. All three cases have mild liver disease but they seem otherwise unaffected. To study this further,...
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