Article
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.
Transgenic research - 1 Jun 2006
Luka Zigmund, Capdevila Antonieta, Mato José M, Wagner C
Abstract excerpt
Three human cases having mutations in the glycine N-methyltransferase (GNMT) gene have been reported. This enzyme transfers a methyl group from S-adenosylmethionine (SAM) to glycine to form S-adenosylhomocysteine (SAH) and N-methylglycine (sarcosine) and is believed to be involved in the regulation of methylation. All three cases have mild liver disease but they seem otherwise unaffected. To study this further,...
Topics
- Animals
- DNA Methylation
- Disease Models, Animal
- Genetic Techniques
- Glycine N-Methyltransferase
- Homozygote
- Humans
- Liver
- Metabolism, Inborn Errors
- Mice
- Mice, Knockout