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The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression

24 Sept 2020

Abstract excerpt

ERα positive breast cancer accounts for 70% of breast malignancies. Compared with ERα negative types, ERα positive breast cancer could be effective controlled by endocrine therapy. However, more than half of the patients will develop endocrine resistance, making it an important clinical issue for breast cancer therapy. Endocrine resistance might be caused by multiple alternations, including the components of ERα...

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PMID: 32973333
DOI: 10.1038/s41388-020-01464-z

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