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Article

Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α.

Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2017

Iizuka Masayoshi, Susa Takao, Tamamori-Adachi Mimi, Okinaga Hiroko, Okazaki Tomoki

Abstract excerpt

Estrogen receptors (ER) are important transcription factors to relay signals from estrogen and to regulate proliferation of some of breast cancers. The cycling of estrogen-induced DNA binding and ubiquitin-linked proteolysis of ER potentiates ER-mediated transcription. Indeed, several transcriptional coactivators for ER-dependent transcription ubiquitinate ER. Histone acetyltransferase (HAT) Hbo1/KAT7/MYST2,...

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Share to Estrogen Receptor alpha
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28769019
DOI: 10.2183/pjab.93.030
PMCID: PMC5713178

Genes

KAT7

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