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Novel RING E3 Ubiquitin Ligases in Breast Cancer

1 Aug 2006

Abstract excerpt

Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways. RING E3 ligases promote the ubiquitination of proteins that are essential to a variety of cellular events. Identification of which ubiquitin ligases specifically affect distinct cellular processes is essential to the development...

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PMID: 16925951
DOI: 10.1593/neo.06469

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