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Elucidation of Mechanisms Underlying Proteasome Addiction in Sarcomas

2026-01-28

Abstract excerpt

<h4>Background: </h4> /Objectives Proteasome inhibitors are approved to treat multiple myeloma and mantle cell lymphoma, and their efficacy in various solid tumors is under investigation. Recent reports suggest proteasome addiction in Ewing, osteo- and some soft tissue sarcomas. Mechanistic explanations generally cite proteotoxic stress. We aimed to clarify mechanism and investigate potentially safer therapeutic a...

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Literature Corpus work
0a3f8f18-1ddb-501a-a5fc-87f49b8ec397
DOI
10.20944/preprints202601.2118.v1
Open publication

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