Article

Transcriptional profiling of human brain cortex identifies novel lncRNA-mediated networks dysregulated in amyotrophic lateral sclerosis

2024-03-19

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease for which a comprehensive knowledge about the pathological mechanisms is still lacking. A multitude of dysregulated cellular processes and pathways have been linked to ALS so far, including the recent focus directed toward the implication of several classes of non-coding (nc)RNAs. Within this context, the class of long ncRNAs (lncRNAs), may provide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27345145-c3c6-599f-b733-74f3fedb56af
DOI: 10.1101/2024.03.18.585481

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling of human brain cortex identifies novel lncRNA-mediated networks dysregulated in amyotrophic lateral sclerosisDOI 10.1101/2024.03.18.585481Read

Single-nucleus transcriptome atlas of orbitofrontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanismsSemantic proximity Read

Pathology-defined cell states reveal reproducible transcriptomic signatures across ALS cortical single-nucleus RNA-seq studiesSemantic proximity Read

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologySemantic proximity Read

Single-nucleus multiome analysis of human cerebellum in Alzheimer’s disease-related dementiaSemantic proximity Read

Transcriptional pathways of definitive ALS genes implicate novel disease-associated target genesSemantic proximity Read

Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis.Semantic proximity Read

Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: insights into pathogenesisSemantic proximity Read

Integrated Spatial and Single-Nuclei Transcriptomic Analysis of Long Non-Coding RNAs in Alzheimer’s DiseaseSemantic proximity Read

Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathiesSemantic proximity Read

Unraveling the intercellular communication disruption and key pathways in Alzheimer's disease: An integrative study of single-nucleus transcriptomes and genetic associationSemantic proximity Read

Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALSSemantic proximity Read

Unraveling the intercellular communication disruption and key pathways in Alzheimer’s disease: an integrative study of single-nucleus transcriptomes and genetic associationSemantic proximity Read