Article

Transcriptional pathways of definitive ALS genes implicate novel disease-associated target genes

2026-07-22

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective degeneration of motor neurons with a substantial genetic contribution to disease risk. Distinct genetic etiologies converge on key pathogenic processes in ALS, including aberrant RNA metabolism, proteostatic stress, dysregulated vesicular transport, and mitochondrial dysfunction. Here, we investigate wheth...

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Literature Corpus work: e8499a75-b002-5c0a-b9af-a1e2d643a062
DOI: 10.64898/2026.07.21.26358605

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