Article

Pathology-defined cell states reveal reproducible transcriptomic signatures across ALS cortical single-nucleus RNA-seq studies

2026-08-13

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a genetically and biologically heterogeneous neurodegenerative disease in which distinct pathogenic mechanisms operate across patients while overt molecular pathology is confined to only a subset of cells. Such features would act to dilute disease-associated transcriptomic signals and complicate the identification of reproducible molecular signatures across the growing number...

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Literature Corpus work: 780a4f63-1af5-52b0-a0ee-ee6483b8df4b
DOI: 10.64898/2026.08.07.743523

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