Article

Gain and loss of progranulin have opposite effects on autophagy

2017-01-01

Abstract excerpt

Progranulin (PGRN) is a widely expressed cysteine-rich, secreted glycoprotein with growth factor-like properties. PGRN is involved in both metabolism and neurodegeneration. It has recently emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity. Individuals with obesity and type 2 diabetes were shown to have increased serum PGRN levels. Heterozygous loss of function mutations in...

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Identifiers and source

Literature Corpus work: 27255079-d701-510c-b2f2-d936c64f23d8
DOI: 10.21954/ou.ro.0000c497

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