Article

Association of Progranulin and Rab2 is required for autophagosome-lysosome fusion

2021-03-30

Abstract excerpt

<title>Abstract</title> <p>Progranulin (PGRN) is a key regulator of lysosome and its deficiency has been linked to various lysosomal storage diseases (LSDs), including Gaucher disease (GD), one of the most common LSD. Here, we report that PGRN plays a previously unrecognized role in autophagy within the context of GD. PGRN deficiency associated with accumulation of LC3-II and p62 in autophagosomes of GD animal mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 006030b9-c027-5ead-af1a-8948144d7061
DOI: 10.21203/rs.3.rs-324970/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Association of Progranulin and Rab2 is required for autophagosome-lysosome fusionDOI 10.21203/rs.3.rs-324970/v1Read

Progranulin Associates With Rab2 and Is Involved in Autophagosome-Lysosome Fusion in Gaucher DiseaseSemantic proximity Read

Progranulinopathy: A diverse realm of disorders linked to progranulin imbalancesSemantic proximity Read

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.Semantic proximity Read

Gain and loss of progranulin have opposite effects on autophagySemantic proximity Read

Association Between Progranulin and Gaucher Disease.Semantic proximity Read

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.Semantic proximity Read

PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases.Semantic proximity Read

The lysosomal function of progranulin, a guardian against neurodegeneration.Semantic proximity Read

PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseasesSemantic proximity Read

Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN HaploinsufficiencySemantic proximity Read

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology.Semantic proximity Read

Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease.Semantic proximity Read