Article

Progranulin Associates With Rab2 and Is Involved in Autophagosome-Lysosome Fusion in Gaucher Disease

2021-05-07

Abstract excerpt

<title>Abstract</title> <p>Progranulin (PGRN) is a key regulator of lysosome and its deficiency has been linked to various lysosomal storage diseases (LSDs), including Gaucher disease (GD), one of the most common LSD. Here, we report that PGRN plays a previously unrecognized role in autophagy within the context of GD. PGRN deficiency associated with accumulation of LC3-II and p62 in autophagosomes of GD animal mo...

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Literature Corpus work: 0c29eabb-63a8-5b75-b87e-624c37bfed8c
DOI: 10.21203/rs.3.rs-457451/v1

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