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Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances

11 Nov 2023

Abstract excerpt

Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a secreted growth factor that implicates in a multitude of processes ranging from regulation of tumorigenesis, inflammation to neural proliferation. Compelling evidence indicating that GRN mutation can lead to various common neuronal degenerative diseases and rare lysosomal storage diseases. These findings have unveiled a critical...

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PMID: 37981505
DOI: 10.1016/j.cytogfr.2023.11.001

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